Table 3 Genetic correlations (rg) calculated via BOLT-REML for the cancer pairs at P < 0.05
Cancer type 1 | Cancer type 2 | rg (95% CI) | P |
|---|---|---|---|
BioBank Japan 1 (BBJ1) | |||
Colorectal | Gastric | 0.30 (0.17–0.43) | 5.8 × 10−6 |
Breast | Lung | 0.37 (0.20–0.54) | 2.1 × 10−5 |
Breast | Prostate | 0.21 (0.10–0.31) | 8.4 × 10−5 |
Gastric | Lung | 0.29 (0.11–0.46) | 0.0014 |
Cervical | Lung | 0.46 (0.16–0.76) | 0.0030 |
Esophageal | Gastric | 0.23 (0.06–0.39) | 0.0069 |
Hepatocellular | Lung | 0.38 (0.10–0.67) | 0.0085 |
Gastric | Hepatocellular | 0.30 (0.06–0.53) | 0.013 |
Lung | Pancreatic | −0.47 (−0.90 to −0.05) | 0.030 |
Colorectal | Pancreatic | 0.36 (0.03–0.68) | 0.032 |
Cervical | Esophageal | 0.29 (0.02–0.55) | 0.033 |
Endometrial | Non-Hodgkin’s lymphoma | 0.57 (0.03–1.00) | 0.037 |
Gastric | Non-Hodgkin’s lymphoma | 0.27 (0.01–0.53) | 0.046 |
UK Biobank (UKB) | |||
Colorectal | Lung | 0.32 (0.19–0.45) | 2.3 × 10−6 |
Breast | Endometrial | 0.39 (0.15–0.62) | 0.0014 |
Breast | Prostate | 0.094 (0.03–0.16) | 0.0052 |
Esophageal | Lung | 0.23 (0.03–0.44) | 0.025 |
