Fig. 5: Potential biomarkers for clinical outcomes.
a Bubble plot illustrates the enrichment of baseline gene alterations in patients with early PFS events (<6 m) versus those with late PFS events (≥6 m). The difference of gene alteration frequency between two groups of patients is plotted on the x-axis. The dash line indicated a P = 0.05. FLT4, MTOR, and TSC2 shared the same dot as the frequency difference of these genes are the same; PTP53 = 0.028323, V = 0.184, Chi-square test without adjustment for multiple comparisons was used for statistical analysis, df = 1; Effect size V was measured by Cramer’s V. b, c Lower tumor mutation load at baseline (Mann-Whitney U Test, two-sided, P = 0.028) and C2D1 (Mann-Whitney U Test, two-sided, P = 0.013) distinguish patients with early PFS events (<6 m, baseline n = 76, C2D1 n = 70) from those with late PFS events (≥6 m, baseline n = 66, C2D1 n = 65); d In comparison to non-responding tumors (n = 82), responding tumors (n = 53) had lower mutation load after one month of treatment (Mann-Whitney U Test, two-sided, P = 0.029). Box-and-whisker plots display box limits, whiskers and outliers, which can be calculated by IQR (Inter Quartile Range, Q3-Q1). The center line in the box plots represents the median; the upper limit of the box plots represents the 75th percentile (Q3); the lower limit of the box plots represents the 25th percentile (Q1); the upper whisker is the maximum value of Q3 + 1.5IQR; and the lower whisker is the minimum value of Q1-1.5IQR. The outlier is defined as a value less than Q1-1.5IQR or greater than Q3 + 1.5IQR. Outliers are showed as point in the box plots. Source data are provided as a source data file.
