Fig. 3: Tisp40 deficiency aggravates cardiac remodeling and dysfunction following I/R injury. | Nature Communications

Fig. 3: Tisp40 deficiency aggravates cardiac remodeling and dysfunction following I/R injury.

From: Tisp40 prevents cardiac ischemia/reperfusion injury through the hexosamine biosynthetic pathway in male mice

Fig. 3

a Heart samples were collected for Wheat Germ Agglutinin (WGA) staining to quantify the cross-sectional area of cardiomyocyte 4 weeks post-I/R surgery (n = 6). b Quantitative results of heart weight/tibial length (HW/TL) 4 weeks post-I/R surgery (n = 6). c Heart samples were collected for picrosirius red (PSR) staining to quantify the collagen deposition 4 weeks post-I/R surgery (n = 6). d Total and insoluble collagen content in the heart 4 weeks post-I/R surgery (n = 6). e–g Cardiac function of Tisp40 KO mice or WT littermates was analyzed by transthoracic echocardiography at the indicated time points, and presented as fractional shortening (FS), left ventricle internal diameters at diastole (LVIDd), systole (LVIDs) or interventricular septal thickness at systole (IVSs) (n = 6). All data are expressed as the mean ± SD, and analyzed using one-way ANOVA followed by Tukey post hoc test. For the analysis in (e–g), repeated measures ANOVA followed by Sidak post hoc test was conducted. *P < 0.0001. Source data are provided as a Source Data file.

Back to article page