Fig. 1: Methodology and individual samples’ origin and age.

a Overview of the procedure we followed., b Geographical origin and age in years before present (ybp) of the 43 individual samples used in this study as well as the different populations represented in the 1000 Genomes reference panel (ACB: African Caribbean in Barbados, ASW: African ancestry in Southwest USA, BEB: Bengali from Bangladesh, CDX: Chinese Dai in Xishuangbanna, China, CEU: Utah residents with Northern and Western European ancestry, CHB: Han Chinese in Beijing, China, CHS: Southern Han Chinese, CLM: Colombian in Medellin, Colombia, ESN: Esan in Nigeria, FIN: Finnish in Finland, GBR: British in England and Scotland, GIH: Gujarati Indian from Houston, Texas, GWD: Gambian in Western Divisions in the Gambia, IBS: Iberian populations in Spain, ITU: Indian Telugu from the UK, JPT: Japanese in Tokyo, Japan, KHV: Kinh in Ho Chi Minh City, Vietnam, LWK: Luhya in Webuye, Kenya, MSL: Mende in Sierra Leone, MXL: Mexican ancestry in Los Angeles, California, PEL: Peruvian in Lima, Peru, PJL: Punjabi from Lahore, Pakistan, PUR: Puerto Rican in Puerto Rico, STU: Sri Lankan Tamil from the UK, TSI: Toscani in Italy, YRI: Yoruba in Ibadan, Nigeria). WGS: whole genome sequencing; DoC: depth of coverage; PC: principal component; ROH: runs of homozygosity. Made with Natural Earth. Free vector and raster map data @naturalearthdata.com.