Fig. 2: GC Structural rearrangement signatures (RSs).

a Six RSs (RS1–RS6) were extracted using non-negative matrix factorization. The stability of the RS is shown in Supplementary Figure 10. The X-axis shows 80 categories by combining SV size (<1 kb, 1–10 kb, 10–100 kb, 100 kb–1 Mb, 1–10 Mb, > 10 Mb), SV type, distribution (clustered or non-clustered), and chromatin status (active or inactive). The Y-axis indicates the probability for each category. The color bars denote the SV types: deletion, red; tandem duplication, green; inversion, cyan; translocation, light grey; and transposition, purple. b Unsupervised hierarchical clustering of 170 cases based on RS contribution elucidated seven RS subtypes (abbreviated as st.RS1–st.RS6, and st.RS2/6 in Figures). Clinical information and genomic features are shown at the top of the Figure. If no data is available, a field is left blank. The RS contributions and numbers in each case are shown by the colors (orange, RS1; light grey, RS2; green, RS3; vermillion, RS4; purple, RS5; indigo, RS6). The total number of single nucleotide mutations is shown at the bottom of the Figure. Representative Circos plots for each RS subtype are shown. c Kaplan–Meier survival analysis of the RS subtypes. The left panel shows the survival curves of seven RS subtypes, and the right panel presents the survival curves of RS6-dominant subtypes (subtypes RS6 and RS2/6) compared with other subtypes. P-values are calculated using the log-rank test. a–c, Source data are provided as a Source Data file.