Fig. 3: SIVETs elicit host T-cell responses. | Nature Communications

Fig. 3: SIVETs elicit host T-cell responses.

From: Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

Fig. 3

a Schematic of the experiment. The following conditions were investigated: (1) no treatment controls (NT), (2) T cell only depots (TcellOnly_Depot), (3) SIVET with antigen-free FLT3L vaccine (SIVET_ FLT3L), (4) SIVET with antigen-free GMCSF vaccine (SIVET_ GMCSF), (5) antigen-free GMCSF vaccine-only depot (Vax_GMCSF) and (6) antigen-free FLT3L vaccine-only depot (Vax_ FLT3L). b, c Proportions of IFN-γ-expressing host CD8+ T cells isolated from lymph nodes (b) and spleens (c) after in vitro antigen re-stimulation. d, e Proportions of IFN-γ-expressing host CD4+ isolated from lymph nodes (d) and spleens (e) after in vitro antigen re-stimulation. P-values were determined using two-tailed one-way ANOVA with Geisser–Greenhouse correction. Pairwise P-values were determined by performing Tukey. Adjusted P-values < 0.05 are shown. Data are mean ± s.d. from n = 4 mice per condition for a single experiment.

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