Fig. 2: The regulatory helix binds to both NBD1 and NBD2 of SUR2A.
From: The inhibition mechanism of the SUR2A-containing KATP channel by a regulatory helix
a The Close-up view of the electron density map at the R helix region. The color scheme is the same as that in Fig. 1. The map was contoured at 0.63 level (4.6 σ). b The binding between the R helix and the two NBDs of SUR2AIF/MgATP/MgATP in the same view as in (a). The amino acids involved in the interactions between the R helix and NBD are shown as sticks. c The detailed interactions between the R helix and NBD1. d The detailed interactions between the R helix and NBD2. e Sequence alignment of the R helix from Homo sapiens SUR1 (hsSUR1), Rattus norvegicus SUR1 (rnSUR1), Capra hircus SUR1 (chSUR1), Sus scrofa SUR1 (ssSUR1), and SUR2 from the same species. R helix is shown as a yellow cylinder. The amino acids on the R helix that are important for interaction with NBD1 and NBD2 are marked with asterisks above. The insertions in SUR1 are boxed in red.
