Fig. 3: Turicibacter colonization alters circulating host bile species in a strain-specific manner.
From: Gut microbiota Turicibacter strains differentially modify bile acids and host lipids
Serum abundances of a–d, primary unconjugated bile acids; e, f secondary unconjugated bile acids; or g–l primary conjugated bile acids. Points indicate log-transformed value for individual mouse with shapes and colors matching Fig. 1, error bars represent mean +/− SEM, a.u.=arbitrary units. Kruskal–Wallis test across all noted colonizations with Dunn’s multiple comparisons to GF for a–f. Kruskal–Wallis test between noted Turicibacter strains and multiple comparisons to H121 for g–l. Mann–Whitney test used to compare GF and MOL361 in g–l, and p-values are noted above GF data points. n for each group: GF = 9, MOL361 = 9, 1E2 = 7, H121 = 10, T129 = 7, CONV = 6. Dotted bar represents ANOVA statistic for groups below the line. Error bars are mean +/− SEM, *p < 0.05, **p < 0.005. Corrected p-values (ANOVA/GF-MOL361/GF-1E2/GF-H121/GF-T129/GF-CONV): 2a = (0.0204/0.1785/0.0141/0.0049/0.999/0.999); 2b = (0.0116/0.5123/0.0919/0.0059/0.9256/0.999); 2c = (0.0208/0.999/0.5425/0.5306/0.999/0.4158); 2d = (0.0216/0.4850/0.1029/0.0201/0.8856/0.999); 2e = (0.0121/0.3585/0.0299/0.0405/0.7612/0.999); 2f = (0.2203/0.6556/0.6645/0.0580/0.999/0.4012). Corrected p-values (ANOVA/H121-MOL361/H121-1E2/GF-MOL361): 2g = (0.0798/0.0564/0.3171/0.1135); 2h = (0.1047/0.0963/0.2315/0.400); 2i = (0.0528/0.0351/0.2726/0.0907); 2j = (0.0407/0.0508/0.0806/0.2973); 2k = (0.3988/0.3757/0.7675/0.0226); 2l = (0.0769/0.0610/0.2393/0.7176).
