Fig. 1: Direct C-H activation constructed stapled peptides in Trp residues.
From: Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan
a Bioactive C7-cyclization tryptophan-peptide natural products. Chemical tool box for peptide macrocyclization on Trp residue. Current strategies for peptide C-H macrocyclization on C(2)-H Trp (b), C(4)-H Trp and C(7)-H Trp (c); d Late-stage peptide substitution-cyclization via maleimidation on C(7)-H Trp in this work.
