Fig. 4: Synthesis of complex peptides and hybrid molecules through C(7)-H activation chemical ligation.
From: Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan
Reaction conditions: 1 or 4 (0.2 mmol), 6 (0.6 mmol), [RhCp*Cl2]2 (5 mol%), AgNTf2 (20 mol%), Ag2O (1.5 eq), DCM (1.5 mL), 80 °C, 6–12 h.
