Fig. 5: Substrate scope for stapled peptides and removal of the directing group and protecting groups.
From: Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan
a Reaction conditions: 8 (0.12 mmol), [RhCp*Cl2]2 (10 mol%), AgNTf2 (40 mol%), Ag2O (1.5 eq), DCM (10 mL), 80 °C, 24 h; b Reaction conditions: 9j (0.02 mmol), TFA/H2O = 95/5 (1 mL, v/v), room temperature, 4 h.
