Fig. 2: Clinical chemistry analysis of serum from ABC-Myc mice. | Nature Communications

Fig. 2: Clinical chemistry analysis of serum from ABC-Myc mice.

From: Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

Fig. 2

a Quantification of serum AFP levels in normal (n = 4 biologically independent animals) and ABC-Myc (n = 6 biologically independent animals) mice by ELISA. Data are presented as mean ± SD. Unpaired two-sided t-test,**p = 0.0046. b Chemistry panel markers in determination of liver function, kidney function and electrolytes in serum from normal (n = 3 biologically independent animals) and ABC-Myc (n = 4 biologically independent animals) mice. Data are presented as mean ± SD. Unpaired two-sided t-test,****p < 0.0001, **p = 0.0056, *p = 0.0171, ns not significant. ALP Alkaline phosphatase, ALT Alanine transaminase, BUN Blood urea nitrogen. c Complete blood count to determine the changes in red blood cells in blood from normal (n = 3 biologically independent animals) and ABC-Myc (n = 4 biologically independent animals) mice. Data are presented as mean ± SD. Unpaired two-sided t-test,****p < 0.0001, ***p < 0.001, ns not significant. HCT hematocrit, RBC red blood cell, HB hemoglobin, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, RDW red cell distribution width, RSD red cell standard deviation. d Complete blood count to determine the changes in platelets in blood from normal (n = 3 biologically independent animals) and ABC-Myc (n = 4 biologically independent animals) mice. Data are presented as mean ± SD. Unpaired two-sided t-test,****p < 0.0001, ***p < 0.001, **p = 0.0017. PLT platelet, MPV mean platelet volume, PDW platelet distribution width, PCT Plateletcrit. Source data are provided as a Source Data file.

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