Fig. 3: Organoid proteome organization shows similarities with human kidneys.
From: An integrated organoid omics map extends modeling potential of kidney disease
a Venn diagram of the organoid proteome compared with microdissected single glomeruli and tubules proteomes. Four compartments indicate proteins identified in (i) single glomeruli only, (ii) both single glomeruli and organoids, (iii) single tubules only, and (iv) both single tubules and organoids. b Over-representation plots corresponding to Venn diagram compartments in (a) for Gene Ontology (GO) terms related to biological process (BP), molecular function (MF), cellular component (CC), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (Fisher’s exact test, adjusted p-value < 0.05). The x-axis corresponds to the combined score from EnrichR analysis. c Venn diagram (top) with associated over-representation plot (bottom) of terms uniquely mapping to the organoid proteome but not to cultured podocyte proteome. d Protein copy number based on intensity based absolute quantification (IBAQ) of podocyte markers expressed in organoids (n = 3) compared to human tissue (n = 2), mouse tissue (n = 3) and cultured human podocytes (undifferentiated and differentiated, both n = 3). Human (H); Mouse (M). Data are represented as mean ± SEM. Source data are provided as a Source Data file. Source data are provided as a Source Data file.
