Table 2 Association of trans fatty acids (elaidic acid, palmitelaidic acid, and linoelaidic acid) with odds of prostate cancer case status

From: Circulating trans fatty acids are associated with prostate cancer in Ghanaian and American men

 

Ghanaian

African American

European American

median

median

median

concentration

Control

Case

Multivariablea

concentration

Control

Case

Multivariablea

concentration

Control

Case

Multivariablea

(µg/ml)

N

N

OR (95% CI)

(µg/ml)

N

N

OR (95% CI)

(µg/ml)

N

N

OR (95% CI)

Elaidic acid

Low

2.89

219

143

Ref.

9.93

154

99

Ref.

10.46

128

70

Ref.

Intermediate

4.11

219

169

1.55 (1.03, 2.35)

17.06

122

128

1.83 (1.25, 2.68)

17.67

160

134

1.38 (0.94, 2.03)

High

6.54

220

273

1.92 (1.30, 2.84)

34.41

105

180

2.98 (2.04, 4.34)

33.25

176

235

2.17 (1.51, 3.12)

Ptrend

   

0.001

   

1.80E-08

   

1.20E-05

Palmitelaidic

acid

Low

1.73

220

105

Ref.

2.86

172

140

Ref.

3.08

109

75

Ref.

Intermediate

2.71

218

178

1.51 (0.98, 2.32)

4.44

130

135

1.43 (1.00, 2.05)

4.57

153

139

1.31 (0.89, 1.93)

High

4.25

220

302

2.26 (1.50, 3.39)

6.76

79

132

2.55 (1.73, 3.77)

7.15

202

22

1.49 (1.04, 2.14)

Ptrend

   

6.90E-05

   

3.10E-06

   

0.035

Linoelaidic acid

Low

3.50

219

153

Ref.

5.91

178

125

Ref.

6.11

104

61

Ref.

Intermediate

4.72

220

148

0.97 (0.64, 1.46)

8.80

117

158

2.17 (1.52, 3.10)

9.06

165

129

1.26 (0.84, 1.88)

High

6.70

219

284

1.52 (1.03, 2.23)

14.01

86

124

2.34 (1.59, 3.45)

14.81

195

249

1.93 (1.32, 2.82)

Ptrend

   

0.025

   

7.10E-06

   

1.70E-04

  1. aLogistic regression adjusted for age at recruitment, BMI, education, diabetes, smoking history, and aspirin use Elaidic acid tertile cutoffs for NCI-Maryland cohort were 13.51 and 22.69 µg/ml.
  2. Elaidic acid tertile cutoffs for NCI-Ghana cohort were 3.47 and 4.98 µg/ml Palmitelaidic acid tertile cutoffs for NCI-Maryland cohort were 3.70 and 5.51 µg/ml Palmitelaidic acid tertile cutoffs for NCI-Ghana cohort were 2.21 and 3.25 µg/ml Linoelaidic acid tertile cutoffs for NCI-Maryland cohort were 7.37 and 10.84 µg/ml Linoelaidic acid tertile cutoffs for NCI-Ghana cohort were 4.09 and 5.34 µg/ml.
  3. Tertile cutoff were determined using distribution of the fatty acids in the control population for each study population, OR Odds Ratio, CI Confidence Interval.
  4. Ptrend ≤ 0.05 indicate significant associations in the multivariable logistic regression analysis.
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