Fig. 2: Paired short-variant analysis from 134 diagnosis/relapse sample pairs.
From: The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma
Each column represents one patient and variants are not classified as either somatic or germline. Three cases had diagnosis-only mutations: patient 51 (NF1 c.6643-3del), patient 101 (RAD51D p.Gln175Ter) and patient 163 (BARD1 p.Val767Ala). Patient 139 had a relapse-only mutation in PALB2 (p.Lys1163Glu). Abbreviations: Pt - Platinum. HGSC - High grade serous carcinoma, HGEC - High grade endometrioid carcinoma. Tumour stage refers to stage at the time of diagnosis; Age refers to age at study entry; Lines of chemotherapy refers to the number of lines of chemotherapy prior to enrolment into BriTROC-1. Diagnosis-Reg denotes the interval (in months) between diagnosis and registration into BriTROC-1.
