Fig. 4: Unpaired copy number signatures.

A Copy number signature spectrum across all samples. Stacked bar plots do not align between diagnosis and relapse groups due to different sample numbers (n = 126 and n = 139, diagnosis and relapse, respectively). B Boxplot demonstrating the unpaired copy number signature exposures between the diagnosis and relapse tumours (n = 126 and n = 139, diagnosis and relapse, respectively). Individual data points are overplotted. Statistics shown is a two-sided Mann–Whitney U test, without adjustments for multiple comparisons. C Boxplot demonstrating copy number signature distributions in unpaired copy number between diagnosis and relapse tumours, stratified by platinum status (n = 30, n = 36, n = 96, and n = 103, diagnosis resistant, relapse resistant, diagnosis sensitive, and relapse sensitive, respectively). Statistics shown is a two-sided Mann–Whitney U test, without adjustments for multiple comparisons. Boxplots show the lower and upper hinges corresponding to the first and third quartiles (the 25th and 75th percentiles). The whiskers extend from the hinge to the largest value no further than 1.5 × interquartile range from the hinge.