Fig. 6: Multiple genic compartments compete for or share nuclear condensates.
From: A model for organization and regulation of nuclear condensates by gene activity
a The ratio (kT,A/kT,B) of gene activity between gene-A and gene-B is increased by increasing the magnitude of gene activity kT,A from 10−4 to 100 while keeping kT,B = 1.0 fixed. The steady state concentration profile of the protein is shown in blue for different values of the ratio (kT,A/kT,B). The right panel plots the centroid and eccentricity of the dense phase of protein for different values of the ratio (kT,A/kT,B). Refer the Analyses section of Methods for more details on how the centroid and eccentricity are calculated. b The ratio of compartmentation (σA/σB) of gene activity is increased by increasing σA from 1.0 to 10.0, while keeping σB = 4.0 fixed. The steady state concentration profile of the protein is shown in blue for different values of the ratio (σA/σB). The right panel plots the centroid and eccentricity of the dense phase of protein for different values of the ratio (σA/σB). c The steady state concentration profile of the protein is shown in blue for different values of distance (r) between the centers of gene-A and gene-B. The right panel plots the centroid and eccentricity of the dense phase of protein for different values of r. Please refer to Supplementary Table 6 for details of simulation parameters.
