Fig. 7: RiPPs discovered with seq2ripp pipeline.

Two lassopeptides and a lanthipeptide discovered from Streptomyces (a, b) NRRL B-2660 and (c) WC-3904, respectively. In each BGC, the precursor gene is colored in black, core biosynthetic genes are colored in green, and the transport-related genes are colored in yellow. The width and location of the boxes demonstrate the relative length and position of each gene. Below each BGC, the precursor sequence is listed with the core sequence underscored. The structures of the core peptide, the mature peptide, and the tailoring enzymes related to the PTMs are shown. PTMs are highlighted in green and circled in mature peptides. d A novel BURP-domain-derived cyclic pentapeptide was discovered from Elaeagnus pungens. BURP domain is highlighted in green and core sequences are colored in black. The chemical structure of elaeagnin is also shown at the bottom. Modification sites are emphasized by red dashed circles. MS/MS annotations for these three compounds are illustrated in Supplementary Figure 5–7. Structure elucidation of elaeagnin is shown in Supplementary Figure 20.