Fig. 5: Rapid kinetics of ISG expression associated with virus clearance in PWK x K18-hACE2. | Nature Communications

Fig. 5: Rapid kinetics of ISG expression associated with virus clearance in PWK x K18-hACE2.

From: Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19

Fig. 5

a Violin plots depicting expression levels of individual ISGs identified in Visium spatial transcriptomics analysis. b In-situ hybridization for SARS-CoV-2 nucleic acid in lung from male K18-hACE2 and PWK x K18-hACE2 mice at 3 and 6 dpi. Scale bars represent 1000 μm; scale bars in insets represent 50 μm. Biological replicates were examined over at least two experiments and 3 male mice/strain/timepoint were randomly selected for assessment of virus distribution by in-situ hybridization. Images are representative of biological replicates.

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