Fig. 1: Concept of CISS-based enantioseparation for CoPc helical supramolecules.

a A schematic illustration of emergent spins via CISS effect in chiral objects and its enantiospecific interaction with the magnetized substrates. The orientation of the anti-parallel spin pair is prescribed by the handedness of the system. For Ni spins, the horizontal (in blue or red) and vertical (in black) arrows describe the rotation and the spin direction, respectively. The black arrows pointing from the chiral molecules to magnetic substrates indicate the interaction between them. Longer arrows represent stronger interaction. b Molecular structure of the achiral Cobalt Phthalocyanine (CoPc). c Typical SEM images of synthesized helical suprastructures. Obtained helices have (Left) single-, (Center) double-, and (Right) even larger number of stranded structures. The yellow scale bars in each SEM image represent 1 μm. d Schematics of the physical vapor deposition (PVD) configurations for the test of CISS-based enantioseparation of helical supramolecules. The shaded red color represents the temperature profiles of the furnace (left and right sides are 500 and 100 °C, respectively). The powder of CoPc molecules heated at 500 °C is transferred to the right side by Ar flow, which is gradually cooled down to 100 °C to promote the crystallization of supramolecules. The synthesized supramolecules are captured by Si substrates covered by Ni. Note that our finite-element simulation on fluid dynamics has found no identification of any complicated motion of gas flow such as vortex motion in the PVD tube (see Supplementary Fig. 7 for more details).