Fig. 3: Selective blockade of MPFC-to-LH circuit affected inter-areal coordination. | Nature Communications

Fig. 3: Selective blockade of MPFC-to-LH circuit affected inter-areal coordination.

From: Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques

Fig. 3

a Experimental setup for simultaneous neural recordings. LFP, local field potential. b Changes of normalized coherence by DCZ injections. The ordinate is in a logarithmic scale. c Quantitative analysis of coherence differences between pre-DCZ and post-DCZ conditions. The ordinate is in a logarithmic scale. Areas enclosed by red lines indicate significant decreases (P < 0.01, flood-fill method). Areas enclosed by white lines indicate significant increases (P < 0.01, flood-fill method). d Proportion of channel pairs with significant Granger causality (GC). The abscissa is in a logarithmic scale. n = 11 sessions for each frequency bin. e Differences in GC in the MPFC-to-LH direction between post-DCZ and pre-DCZ conditions. The abscissa is in a logarithmic scale. Analysis period, 1–250 ms from stimulus onset. Data are mean ± SEM. Red circles, P < 0.05 (one-sided paired t-test). n = 11 sessions for each frequency bin. Source data are provided as a Source Data file.

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