Fig. 1: Increased ANGPTL8 and LILRB/PirB in the liver in human and murine NASH.
From: LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
a–c LILRB2 mRNA levels in the livers of NASH patients from GEO datasets (GSE126848, GSE167523, and GSE130970). d ANGPTL8 mRNA levels in the livers of NASH patients from GEO datasets (GSE136103). e Representative images showing immunofluorescence staining of PirB and ANGPTL8 in liver tissues. f Liver PirB and Angptl8 mRNA expression in 6-month CDHFD-fed and 2-month MCD-fed mice. g Western blot analysis of liver PirB and ANGPTL8 protein in 6-month CDHFD-fed and 2-month MCD-fed mice. Uncropped blots are provided in Source Data. Scale bar, 100 µm. All samples are biologically independent replicates and n indicates the number of biologically independent samples examined. Data shown are representative of four independent experiments with similar results (e, g). The data are shown as the mean ± s.e.m. (n = 6 mice/group) and were statistically analyzed by one-way ANOVA with Tukey’s multiple-comparison test (a, c, d, f) or two-tailed Student’s t-test (b). All the p values were two-sided and adjustments were made for multiple comparisons. kD relative molecular weight in kilodalton, ND normal diet, CDHFD choline-deficient high-fat diet, MCD methionine-choline deficient. Source data are available as a Source Data file.
