Fig. 5: Imputation of individual-specific epigenomic patterns.

a Sigmoid Colon-H3K4me3 track spanning 800kb and showing consistent patterns for all four individuals. For the central peak, we display a slice across the epigenomic tensor demonstrating signal conservation across tissues and individuals. b Occupancy histograms for the enriched bins across tissues. c Occupancy histograms for the overlap of enriched bins across individuals. d Occupancy across tissues and individuals for each enriched bin in the tracks for Male 37 for the Esophagus Muscularis Mucosa tissue. e Pearson correlation and MSE for the leave-one-tissue-out imputation of chromosome 21 using transfer learning from one training individual to the target individual. n = 72 imputed tracks for the `Training Ind. Track' baseline and eDICE for each assay except H3K36me3, where n = 60. n = 24 for the “AVG” predictor for each assay except H3K36me3, where n = 20. Boxes represent the IQR, with the middle line representing the median; the whiskers represent points that lie within 1.5 IQRs of the lower and upper quartiles. Source data are provided as comma-separated-values (csv) files.