Fig. 2: Differential 5mC and 5hmC marks of OUD. | Nature Communications

Fig. 2: Differential 5mC and 5hmC marks of OUD.

From: Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex

Fig. 2

a Distribution of differential sites into Chromosomal location of hyper- and hypomethylation for 5mC and 5hmC. b Comparison between differential 5mC and 5hmC sites for CpG and gene, showing a gene overlap of 56 annotated genes. c Distribution of differential CpGs across genomic loci showed the promoter region with the highest number of 5mC and 5hmC differential CpGs. d, e Enrichment analysis for neuronal regions showed that 5mC and 5hmC differential CpGs were mostly enriched for neuronal H3K27ac. f Comparison of our differential 5mC and 5hmC CpGs with differential 5mC markers detected in the OFC of opioid overdose cases (Kozlenkov et al.) showed an overlap of 129 genes. g Gene ontology analysis for OUD-associated 5mC genes. h Gene ontology analysis for OUD-associated 5hmC genes. Enrichment analyses were calculated using Fisher exact tests.

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