Fig. 4: Co-methylation of 5mC and 5hmC sites.

a 5mC-significant modules associated with OUD (correlation ≥ |0.4|, p value < 0.05). b 5hmC-significant modules associated with OUD (correlation > ≥|0.4|, p value < 0.05). Correlations were calculated using weighted Pearson correlation, and p value using student asymptotic statistics. c GO enrichment analysis for 5mC-significant modules (top 10 terms). d GO enrichment for 5hmC-significant modules (top 10 terms).