Fig. 4: Maximal and minimal possible \(\frac{[NADH]/[NA{D}^{+}]}{[NADPH]/[NAD{P}^{+}]}\) ratio to reach the respective growth-rate-associated (Sub)MDF value (for wild-type specificity).
From: Network-wide thermodynamic constraints shape NAD(P)H cofactor specificity of biochemical reactions
a Aerobic conditions under MDF. b Aerobic conditions under SubMDF. c Anaerobic conditions under MDF. d Anaerobic conditions under SubMDF. Note that if a blue dot (minimal ratio) is not seen then it largely overlaps with the red dot (maximal ratio) and is thus very close to this value. In all these cases, the maximum value of the \(\frac{\left[{NADH}\right]/[{{NAD}}^{+}]}{\left[{NADPH}\right]/[{{NADP}}^{+}]}\) ratio is below 0.001. Source data are provided as a Source Data file.
