Fig. 6: Maximal thermodynamic driving forces (MDF and SubMDF) achievable with different NAD(P)(H) specificities and feasible ranges of the \(\frac{[NADH]/[NA{D}^{+}]}{[NADPH]/[NAD{P}^{+}]}\) ratio to reach the respective (Sub)MDF value of wild-type specificity (all with acetate as carbon source under aerobic conditions). | Nature Communications

Fig. 6: Maximal thermodynamic driving forces (MDF and SubMDF) achievable with different NAD(P)(H) specificities and feasible ranges of the \(\frac{[NADH]/[NA{D}^{+}]}{[NADPH]/[NAD{P}^{+}]}\) ratio to reach the respective (Sub)MDF value of wild-type specificity (all with acetate as carbon source under aerobic conditions).

From: Network-wide thermodynamic constraints shape NAD(P)H cofactor specificity of biochemical reactions

Fig. 6

a MDF results. b Ratio results with MDF as target. c SubMDF results. d Ratio results with SubMDF as target. Note that if a blue dot (minimal ratio) is not seen then it largely overlaps with the red dot (maximal ratio) and is thus very close to this value. Source data are provided as a Source Data file.

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