Fig. 3: Formation mechanism of the spiky topology. | Nature Communications

Fig. 3: Formation mechanism of the spiky topology.

From: Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma

Fig. 3

a Schematics illustrating the nanostructures with different surface spiky topologies and hollow tail diameters. b–d TEM and (e–g) SEM images of nanostructures prepared at various 4-MPAA concentrations: 5 mM (b, e), 15 mM (c, f), and 25 mM (d, g). Scale bars are 200 nm in (b–d) and 500 nm in (e–g). h Hollow tail diameter and corresponding spike length of nanostructures prepared in different 4-MPAA concentrations. The data are shown as the mean ± s.d. i Tail length at different 4-MPAA concentrations at different time points are shown. The data are shown as the mean ± s.d. Experimental data in (h and i) are mean ± s.d. of samples in a representative experiment (n = 50). j–l Schematic illustration of site-selective superassembly of silica on the 4-MPAA-covered surface of AuNSs at (j) low, (k) moderate and (l) high 4-MPAA concentrations. Source data for the figure are provided within the Source Data file.

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