Fig. 7: Replication origins are more enriched in clustered pG4s than in monomeric pG4s.

a, b Association of origins peaks with genomic features. a SNS Origin peaks data come from either human H9 cells (left), the SNS core origins defined in ref. ²³ (middle) or Ini-seq2 datas from ref. ¹⁶. b SNS Origin peaks data come from chicken DT40 cells (left) or mouse ESCs (right). The numbers above bars indicate the log-odd-ratio of the logistic regression to test enrichment with respect to random segments. ***P < 0.001 by the Wald test (see “Methods”). The negative LOR indicates that when origins are associated with a pG4s, the enrichment is towards the clustered form (LOR > 0) rather than the monomeric form (LOR < 0). c Origin strength detected in CGI (left) and non-CGI (right) is related to the number of monomeric (blue) and clustered (pink) pG4 associated in human and chicken cell lines. Origins strength is defined as the number of reads mapping within the origin divided by the length of the origin. Error bars correspond to a 95% two-sided confidence interval. The number of origins is provided in Supplementary Tables 3 and 4.