Fig. 2: EV-sorting ability of candidate proteins.
From: Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
a Overview of all 244 candidates plotting total secreted Tluc against percentage of intravesicular Tluc. EV-sorting proteins were defined to have a percentage of intravesicular Tluc above zero (yellow area) and are shown in the grouped dot plot. The value refers to the percentage of intravesicular Tluc. Proteins are marked with gene names. b Correlation between the rank regarding total secreted Tluc and the rank regarding total secreted Tluc/Nluc ratio. c Correlation of the percentage of intravesicular Tluc obtained from the primary and repeat screening. d Correlation of the rank regarding secreted Tluc or secretion efficiency between the primary and repeat screening. Results in (a, b) were from the primary screening and are shown as mean ± standard deviation of five biological replicates. Data from the repeat screening are shown as mean ± standard deviation of three biological replicates. In the scatter plots, each dot refers to one candidate and the red dot indicates the benchmark CD63. The degree of correlation was analyzed with linear regression and is shown as goodness-of-fit (R2) and significance of non-zero slope (P). Source data are provided as a Source Data file.
