Fig. 9: Model for the stress-induced recruitment of thermogenesis by olfactory cues in the female brain. | Nature Communications

Fig. 9: Model for the stress-induced recruitment of thermogenesis by olfactory cues in the female brain.

From: A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus

Fig. 9

Stressful cues are detected by olfactory pathways and integrated by the MeA, where increased GABAergic activity in the female brain leads to recruitment of CCK neurons from the DMH and stress-induced thermogenesis through BAT activation and suppression of food intake. Recruitment of CRH neurons in the PVH drives CORT release through HPA axis stimulation, in a process that might depend on the activation of CCK neurons. Cholecystokinin (CCK), corticotropin-releasing hormone (CRH), corticosterone (CORT), dorsomedial hypothalamus (DMH), hypothalamic-pituitary-adrenal (HPA) axis, main olfactory bulb (MOB), medial amygdala (MeA), olfactory cortex (OC), olfactory tubercula (OT), paraventricular nucleus of the hypothalamus (PVH), piriform cortex (PC).

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