Fig. 3: Scope of aldehydes. | Nature Communications

Fig. 3: Scope of aldehydes.

From: Photoredox cobalt-catalyzed regio-, diastereo- and enantioselective propargylation of aldehydes via propargyl radicals

Fig. 3

All reactions were performed under N2 atmosphere, dr was determined by analysis of 1H NMR spectra of unpurified mixtures, and er was determined by analysis of HPLC spectra. aThe reaction was performed in the presence of 2.0 equiv of propargyl carbonate and 2.0 equiv of Hantzsch’s ester for 17 h. bYield of pure major diastereomer. cThe reaction was performed in the presence of 5.0 mol % (S,S)-5h. 4CzlPN = 1,2,3,5-tetrakis(carbazole-9-yl)−4,6-dicyanobenzene, Hantzsch’s ester = diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate.

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