Fig. 6: CS-CORE estimates in monocytes from control subjects and COVID-19 patients.
From: Cell-type-specific co-expression inference from single cell RNA-sequencing data
Known interferon-stimulated genes are colored in red. Genes in the SARS-CoV-2 infection Reactome pathway are colored in brown. * is used to mark genes that belong to both gene sets. We performed a differential co-expression analysis on top 1000 highly expressed genes in monocytes and obtained modules of genes that shared similar changes in co-expressions between cells from COVID-19 patients and controls. For a differentially co-expressed gene module enriched for the interferon signaling pathway, we focused on genes that had strong differential signals (sum of absolute differential co-expressions greater than the median) and visualized the co-expression network estimates in control subjects and COVID-19 patients. Source data are provided as a Source Data file.
