Fig. 9: Schematic of the NMR sequences used in this study.

These sequences are \({{{{{\rm{\varphi }}}}}}\)-FID (a), 45o-out-of-phase echo (OPE) (b), \({{{{{\rm{\varphi }}}}}}\)-CPMG (c), and ESOTHERIC53 (d). In the case of thermal polarization, \({{{{{\rm{\varphi }}}}}}\) = 90o results in maximum polarization (in a and c), while in the case of PHIP (PASADENA7), \({{{{{\rm{\varphi }}}}}}\) = 45o should be used instead. Note that composite refocusing pulses (\({90}_{{{{{{\rm{X}}}}}}}^{{{{{{\rm{o}}}}}}}{180}_{{{{{{\rm{Y}}}}}}}^{{{{{{\rm{o}}}}}}}{90}_{{{{{{\rm{X}}}}}}}^{{{{{{\rm{o}}}}}}}\)) were used, and the difference between (b) and (c) is the signal acquisition (FID or multiple echoes. FID: free induction decay, OPE: out-of-phase echo, CPMG: Carr-Purcell-Meiboom-Gill sequence, n, n1, n2, and n3 are the number of refocusing pulses, ESOTHERIC: efficient spin order transfer to heteronuclei via relayed inept chains.