Fig. 4: A comparison of FAP cells presence between the deconvolution results and smFISH (RNAscope) validation on the D2-mdx. | Nature Communications

Fig. 4: A comparison of FAP cells presence between the deconvolution results and smFISH (RNAscope) validation on the D2-mdx.

From: Spatial transcriptomics reveal markers of histopathological changes in Duchenne muscular dystrophy mouse models

Fig. 4

a D2-mdx model with the indications to the approximate location of zoomed-in smFISH images. b Location of FAPs based on spot deconvolution. c Pdgfra, marker gene for FAPs, expression pattern based on Visium data (d) smFISH results in two regions that confirm the absence (cross) and presence (filled dot) of FAPs as was expected based on the spot deconvolution results. All scale bars in the immunofluorescent images represent 100 µm.

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