Fig. 3: Variance in height explained (R2) by SOCS3 methylation and PRS. | Nature Communications

Fig. 3: Variance in height explained (R2) by SOCS3 methylation and PRS.

From: DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Fig. 3

Longitudinal effects of height PRS and SOCS3m in the MPC cohort, showing percentage of variance apportioned between SOCS3m (mean methylation across all three SOCS3 CpGs measured at 5 years) and height PRS across different time points from birth to early adulthood. Y axis shows the R2 from ANOVA models including both mean SOCS3m and height PRS. Error bars indicate 95% confidence intervals for R2 derived from N = 1000 bootstrap samples. SOCS3m SOCS3 methylation, PRS polygenic risk score, ANOVA analysis of variance, LMIC low- and middle-income countries, HIC high-income countries, MPC Mysore Parthenon Cohort.

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