Fig. 3: Receptors involved in environmental-sensing and nutrient transport in B cells. | Nature Communications

Fig. 3: Receptors involved in environmental-sensing and nutrient transport in B cells.

From: An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells

Fig. 3

a Heat map shows the log2-fold deviation from the mean of normalized copy numbers of 38 receptors that were differentially expressed among T1, T2, MZ and FoB cells (FDR-adjusted p values < 0.05, calculated as in Fig. 1b). The list of receptors was manually curated and includes CD molecules; toll-like receptors; NOD-like receptors; Fc receptors; complement receptors; TNF receptor superfamily; receptors for cytokines such as interleukins, interferons, TGF-β; chemotactic receptors belonging to the CCR, CXCR or sphingosine-1-phosphate families; adhesion molecules; ADAM metalloproteinases and Notch receptors. b–d Graphs display copy numbers per cell of receptors selected based on their biological function. In c, histograms represent CD180 and TACI expression as detected by flow cytometry. e, Copy numbers of the major glucose-, lactate- and amino acid-transporters and selected fatty acid transporters (n = 4 mice; mean ± SD). Source data are provided as Source Data file.

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