Fig. 4: The functional properties of T cells were impaired in non-responders. | Nature Communications

Fig. 4: The functional properties of T cells were impaired in non-responders.

From: Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy

Fig. 4

a Decreased levels of plasma Eotaxin-3, IL-1β, IL-23, TNF-α, MDC, and MCP-4 were observed in responders (n = 11) versus non-responders (n = 14). This box plots represent the interquartile range (IQR), with the horizontal line indicating the median. The whiskers extend to the farthest data point within a maximum of 1.5 × IQR. Data in longitudinal analysis are presented as mean values +/− SD. b In stimulated patient PBMC achieved with Dynabeads Human T-Activator CD3/CD28, secreted cytokines, including IL-1β, IL-2, IL-8, IL-22, and MCP-1, were significantly increased in responders (n = 11) compared with non-responders (n = 14). This box plots represent the interquartile range (IQR), with the horizontal line indicating the median. The whiskers extend to the farthest data point within a maximum of 1.5 × IQR. Data in longitudinal analysis are presented as mean values +/− SD. c High levels of IL-22 remarkably contributed to prolonged PFS. p-value in PFS analysis was examined by the log-rank test. Other p-values were calculated using two-sided t-tests. HD healthy donors, R responder, NR non-responder. Data are presented as mean values +/− SD.

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