Fig. 1: Design and optimization of the ABE8 system for rd10 SNV correction. | Nature Communications

Fig. 1: Design and optimization of the ABE8 system for rd10 SNV correction.

From: AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa

Fig. 1

a Dual-AAV system of SpRY-ABE8e using a split-intein mechanism and sgRNA design targeting the rd10 pathogenic SNV. b Schematic representation of rd10 pathogenic SNV correction by SpRY-ABE8e. c BE efficiency of rd10 pathogenic SNV by dual-AAV plasmids of SpRY-ABE8e. Bars represent the average editing specificity, and error bars represent the s.d. of three independent biological replicates. Source data are provided as a Source Data file.

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