Fig. 2: Dual-AAV-mediated BE therapy in rd10 mice. | Nature Communications

Fig. 2: Dual-AAV-mediated BE therapy in rd10 mice.

From: AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa

Fig. 2

a Flowchart of in vivo ABE treatment. b In vivo genomic DNA and cDNA BE efficiencies in rd10 mice. c Comparison of average editing efficiencies of genomic DNA and cDNA. d Endogenous genome off-target efficiencies after SpRY-ABE8e treatment. Two-tailed unpaired t-tests; adjustment was not made for multiple comparisons. For all plots, the dots represent individual biological replicates, bars represent the average editing specificity, and error bars represent the s.d. of independent biological replicates. BSS treated (n = 6), NT treated (n = 6), and A7 treated (n = 7). Source data are provided as a Source Data file.

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