Fig. 4: Photoreceptor preservation in rd10 mice after ABE treatment. | Nature Communications

Fig. 4: Photoreceptor preservation in rd10 mice after ABE treatment.

From: AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa

Fig. 4

a Representative eye section of an A7-treated rd10 mouse with H&E staining at P35. ONL, outer nuclear layer; INL, inner nuclear layer; and GCL, ganglion cell layer. b Quantification of ONL thickness in DAPI nuclei-stained retinal cryosections of WT (n = 4 eyes), BSS treated (n = 4 eyes), NT treated (n = 4 eyes), and A7 treated (n = 4 eyes) mice at P35. ONH, optic nerve head. Data are presented as means ± s.d. c Immunofluorescence analysis of representative retinal sections at P35. Blue indicates DAPI and red indicates Rhodopsin. OS, outer segments. d Quantification of rod OS length at 1 mm temporal of the optic nerve head of WT (n = 4 eyes), BSS treated (n = 4 eyes), NT treated (n = 4 eyes), and A7 treated (n = 4 eyes) mice at P35. Means ± s.d. are shown. Source data are provided as a Source Data file.

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