Fig. 3: Behavioral space representation differs between dSPNs and iSPNs. | Nature Communications

Fig. 3: Behavioral space representation differs between dSPNs and iSPNs.

From: The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding

Fig. 3

Representative neuronal activation maps of dSPNs (top panels) and iSPNs (bottom panels) during one session for four behaviors (a) and representative example of mouse trajectories during one representative episode of the same behaviors (b). Examples of matrices of pairwise neuronal activation similarity between behaviors (left panels) and matrices of pairwise behavioral similarity between behaviors (right panels) in one session from one representative dSPNs recording (c) and one representative iSPNs recording (d). e For pairs of behaviors, the neuronal activation similarity and behavioral similarity are significantly correlated in both dSPNs and iSPNs, as illustrated by the examples displayed in (c, d) (Spearman correlation two-sided: dSPNs, ***p = 9.9e−27; iSPNs, ***p = 3.0e−13). f Average correlation coefficient (Spearman correlation) between pairwise behavioral and neuronal similarities is higher for dSPNs (red; n = 33 sessions in 8 mice) than iSPNs (blue; n = 40 sessions in 9 mice) (permutation-based two-sided t-test, dSPNs vs. iSPNs: ***p = 0.0005). Data are presented as mean values ± SEM. Source data are provided as a Source Data file.

Back to article page