Fig. 2: Prognostic trifurcation by fraction of encapsulation. | Nature Communications

Fig. 2: Prognostic trifurcation by fraction of encapsulation.

From: An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

Fig. 2

a Overall survival (OS, left) and liver-specific (hepatic) relapse-free survival (hRFS, right), when scored by the predominant growth pattern, replacement, encapsulated, or pushing. b OS and hRFS stratified by the indicated proportions of encapsulation. Two-sided log-rank p-values given in the plots, (a) and (b). OS – predominant growth pattern, p = 0.000075; hRFS – predominant growth pattern, p = 0.000097; OS – three strata, p = 0.000038; hRFS – three strata, p = 0.000676. c Univariate Cox proportional hazard regression using three strata of encapsulation, OS left; hRFS right. OS – 100% encapsulation, p = 0.000063; hRFS – 100% encapsulation, p = 0.000312. d Multivariate Cox proportional hazard analysis using encapsulation in three strata; OS left; hRFS right. Hazard ratio (HR) with 95% confidence interval shown in brackets. Two-sided Wald-test p-value, asterisks represent significance levels; ***p < 0.001, **p < 0.01, *p < 0.05. OS – number of metastases, p = 0.000298; OS – max. tumor diameter (cm), p = 0.000037; hRFS – meta-/synchronous metastases, p = 0.000107; hRFS – number of metastases, p = 0.000070; hRFS – max. tumor diameter (cm), p = 0.000241.

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