Fig. 4: Structure of dog HSD17B13/compound 1 complex.
From: Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13
a conformational changes of HSD17B13 caused by compound 1 (light blue C atoms, stick model) binding. The complex structure was superimposed with the apo dog HSD17B13 structure (gray ribbons). Key residues are labeled. b Detailed interactions of compound 1 with HSD17B13. Residues that contact compound 1 are labeled. c Local conformational changes at dog HSD17B13 brought by mutations into human amino acids (G177E/V178G/T205A). d To demonstrate the modeling quality, compound 1 was shown embedded in the initial 2Fo-Fc electron density map calculated before ligand was modeled.
