Fig. 2: CryoET STA of immature HERV-K VLPs.
From: Molecular architecture and conservation of an immature human endogenous retrovirus
a CryoET STA map of immature HERV-K CA hexamer colored by local resolution (red to blue). b A slab of HERV-K CA hexamer map overlapped with the atomic model (rainbow colors blue to red, N-terminus to C-terminus. c The atomic model of the immature HERV-K CA monomer (NTD in blue, CTD in orange, h12 in red) with α-helices labeled. d The atomic model of the immature HERV-K hexamer viewed from the side and top with one monomer colored in blue and orange. e A central slice of the HERV-K hexamer density map, showing IP6 density with an IP6 fitted (red arrow) and two Lys rings (K166 and K240), in addition to the hydrophobic core of the 6HB (M244 and I248). f, g Density slabs at the top (f, top dashed box in e) and bottom (g, bottom dashed box in e) of the 6HB, with the protruding side chains shown as sticks. h The dimer (black circle) and trimer (red circle) interfaces between adjacent immature HERV-K hexamers. i A detailed view of the trimer interface involving helix 4 with the contributing side chains shown as sticks. j A detailed view of the dimer interface involving helix 9 with the involved side chains shown as sticks.
