Fig. 4: Single-component immunogens have a very similar structure to the AMA1-RON2L complex, with the SBD1 immunogen possessing the greatest structural similarity.
From: Structure-based design of a strain transcending AMA1-RON2L malaria vaccine
a Crystal structures of the single-component SBD1 immunogen (light blue, blue) and insertion fusion immunogens 2 (light pink, magenta) and 3 (cyan, teal). The fused RON2L portion of the immunogen is shaded darker than the AMA1 portion. b Single-component immunogens superimposed on the AMA1-RON2L complex (PDB ID: 3zwz, white and orange). c A focused view of RON2L and the surrounding loops in single-component immunogens superimposed on the AMA1-RON2L complex (PDB ID: 3zwz). An arrow indicates local structural perturbations in the insertion fusion immunogens.
