Fig. 2: Substrate scope for CADA (3 + 2) reaction. | Nature Communications

Fig. 2: Substrate scope for CADA (3 + 2) reaction.

From: Catalytic asymmetric dearomatization of phenols via divergent intermolecular (3 + 2) and alkylation reactions

Fig. 2

Reaction conditions: 1 (0.2 mmol), 2 (0.24 mmol.), CPA-7 (10 mol%), and 5 Å MS (50 mg) in toluene (1 mL) at –30 °C for 12 h, isolated yields, ee and dr values were determined by chiral HPLC analysis, all dr >20:1, PG = NHCO2Bn. awith 3 Å MS (50 mg) and CPA-2 at −40 °C. bwith 3 Å MS (50 mg) and CPA-4 at 25 °C.

Back to article page