Fig. 5: Preliminary applications. | Nature Communications

Fig. 5: Preliminary applications.

From: Catalytic asymmetric dearomatization of phenols via divergent intermolecular (3 + 2) and alkylation reactions

Fig. 5

Reaction conditions: i) 3c (0.2 mmol), CH3MgBr (0.3 mmol.), THF, 0 °C; ii) 3c (0.3 mmol), Pd/C, H2, MeOH, r.t.; iii) 3u (0.2 mmol), NaBH4 (0.2 mmol), MeOH, 0 °C; iv) 3 u (0.2 mmol), TFA (0.2 mL), CH2Cl2, 0 °C; v) 3a (0.2 mmol), ethyl 2-bromoacetate (0.24 mmol), Cs2CO3 (0.3 mmol), CH3CN, r.t.; vi) 3u (0.2 mmol), ethyl 2-bromoacetate (0.24 mmol), Cs2CO3 (0.3 mmol), CH3CN, r.t. then reflux.

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