Fig. 1: Cryo-EM structures of DmDcr-2/R2D2/Loqs-PD in complex with 50-bp and 19-bp dsRNA.
From: Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers
a Schematic of 50-bp and 19-bp dsRNA. b–e The cryo-EM density map and atomic model of the complex in Dimer and Trimer state oligomer. f Color-coded domain architecture of the Trimer state oligomer. DmDcr-2, R2D2, and Loqs-PD are in the same color scheme is used as in (e). The intramolecular interactions are indicated as arrows. Domains participated in the intramolecular in DmDcr-2 are highlighted with Hel2i in yellow, Hel2 in cyan, Pincer in orange-red, RIIIDai in cornflower-blue, RIIIDb in forest-green, RIIIDbi in pink, and C-dsRBD in deep-sky-blue.
