Fig. 2: Locations of R2D2 in the oligomers.
From: Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers
a Take Dimer state for example, R2D2 is located between the two DmDcr-2 monomers and inhibits the binding of the second DmDcr-2 to Loqs-PD. Two DmDcr-2 monomers are shown in surface mode. R2D2 and dsRNA are shown in cartoon mode. b Cryo-EM density and the fitted model of the Helicase domain of the 2nd DmDcr-2. The Loqs-PD binding position is occupied by R2D2. The cryo-EM map was shown at 70% transparency. c Cryo-EM density and the fitted model of the Helicase domain of the 1st DmDcr-2. The densities of Loqs-PD and R2D2 can be well-defined.
